SciLog - SciPure

The SciLog SciPure 200 automates and documents tangential flow filtration (TFF) procedures, i.e. the concentration and washing (diafiltration) of dilute protein solutions. TFF automation is achieved by simultaneously monitoring feed line pressure (P1), retentate line pressure (P2) and permeate line pressure (P3). The SciPure 200 incorporates the pressure data into an exclusive software-driven fluid handling system that automatically controls and adjusts pressure and/or flow rates in the TFF system.

During TFF concentration, the SciPure 200 implements user-definable pressure scans of the trans-membrane pressure (TMP), differential pressure (DP) or feed line pressure (P1). Starting with an optimal, higher pressure,the scan feature provides for continued pressure optimization by allowing for an automated, smooth decrease of the pressure over a user-selected protein concentration range.

Dimensions		SS Platform Length = 36 in. (91 cm); Platform Width = 24 in. (61 cm); Platform Height = 7 in. (18 cm) including 5 OD locking casters. Removable Handle, Height = 39 (99cm)
Weight:		SciPure TFF System = 88 lb (40kg), depending on pump head and reducer.
Power:		230 V, 60 / 50 Hz, double fused. Fuse Rating: 10 A, 250 V, Slow Blow for 1.0 HP motors.
Operating Range:		4 to 40° C, 100% Humidity
Electrical Enclosure:		Sealed electronic enclosure, wash / splash resistant construction. Unlisted NEMA 4 enclosure design.
Display:		Two line LCD, 20 characters each line, back-lit
Data Entry:		Membrane keypad with tactile and auditory response
Pump Heads & Motors:		Pump Heads: AccuLobe Rotary Lobe Pump Head with integral 1:3 Speed Reducer and NEMA motor mount, made by Viking Pumps. For water (1 cps), the maximum pump rate at 0psi backpressure ranges from 0.07 to 3.1 gal./min. Pump Motors: Variable speed motor, continuous duty, 1750 RPM max, 1.0 HP motor is rated for 180 VDC, 10 amperes. Motor Encoder: Optically encoded and servo-controlled; 100 lines per motor revolution.
I/O Ports:		3 Pressure transmitter (4 20mA) inputs; 3 Detector (4-20mA) inputs; 1 Flow meter (4-20mA) input; 1 Scale (RS-232) I/O port; 1 PC/Printer (RS-232) I/O port; 1 Multi-Valve Controller (RS-232) I/O port; 2 Digital I/O ports for level sensors; 1 Analog (4-20mA) output for proportional control valve operation
Flow Meter:		316 SS, Sanitary Turbine Flow Transmitter with ¾ TC connections. 4-20mA output, calibrated flow range: 0.075 gal/min (0.28 liter/min) to 9.0 gal/min (34.0 liters/min). Output Accuracy: +/- 0.5%, linear output range: 0.075 to 7.5 gal/min. The flow meter is located in the TFF filter feed line
Pressure Transmitter:		Three (3), 316 SS, Sanitary Pressure Transmitter with ¾ TC connections, 0 - 100 psi, 4-20mA output. Accuracy: +/-0.25%. Pressure transmitters are located in the TFF feed line (P1), retentate line (P2) as well as in the permeate line (P3).
Temperature Transmitter:		316 SS, Sanitary Temperature Transmitter with ¾ TC connection. 0-100 C, 4-20mA output. Accuracy: +/- 0.18% at 100° C.
Control Valve:		316 SS, Diaphragm Valve, Electro-Pneumatic Proportional Pressure Control Valve with ½ TC connections. Required voltage supply of 24 VDC, 4-20mA signal input for valve positioner. Control Range: 50:1. Supply air pressure: 65-85 psi. The control valve is located in the TFF retentate line
Electronic Scale:		Electronic Scale, 30kg capacity, +/- 0.005kg resolution. NTEP Class III, HACCP sensitive sanitary design. Stainless steel wash-down construction with 12 x 12 platform. Serial communication / hookup. Scale is located on a SS platform above the pump motor to provide gravity flow of retentate into the AccuLobe rotary lobe pump head.
Reservoir:		20 liter polypropylene, retentate reservoir, bottom outlet with shut-off valve. Reservoir cap comes with two (2) ½ barb inlets and one (1) ¼ barb inlet. The 20 liter reservoir is located on the 30 kg scale and has a fluid connection to inlet of the rotary lobe pump.
Diaphragm Valves:		Three (3), 316 SS, manual diaphragm valves with ¾ TC connectors, located in the feed, retentate and permeate lines for isolation of MaxiMate TFF filtration device.
Sampling Valve:		316 SS, Inline Sampling Valve with ¼ TC connections and ¼ hose barb outlet. Located in the feed line at the system low-point. Sampling valve is also used for draining of TFF system.
SS Tubing:		316 SS tubing, custom elbows and tees, electro-polished, ½ TC connections for system assembly.
Maximate:		316 SS, Maximate Filter Holder (Pall Corporation)
Documentation:		Documentation software, place all filtration parameters in Excel and produces charts and graphs. Provides an instantaneous overview of the filtration progress and status.

The SciPure 300 GMP offers production-scale GMP TFF capabilities with a small footprint. The SciPure 300 uses intuitive, menu-driven control software built upon the familiar and reliable Microsoft Windows XP operating system. Click Here to learn more about the SciPure 300 GMP.

SciLog also offers laboratory scale TFF systems that can automate, optimize and document your smaller scale applications. Click Here to learn about the fully automated SciLog PureTec^® System. To learn about the manually controlled SciLog ACCUTec^® System Click Here